Alkylcarbopenems, their preparation, use in pharmaceutical...

C - Chemistry – Metallurgy – 07 – D

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C07D 487/04 (2006.01) C07D 477/20 (2006.01)

Patent

CA 1125292

ABSTRACT Alkylcarbapenems of the formula (I): Image (I) and salts and cleavable esters thereof wherein A is a C=CH-CH3 or CH-CH2-CH3 group and Y is a -S-CH2-CH2-, -S-CH=CH- or -SO-CH=CH- group excluding substantially pure biologically produced (5R,6R)-3- (2-acetamidoethylthio)-6-ethyl-7-oxo-1-azabicyclo [3.2.0]hept-2-ene -2- carboxylic acid and its salts are disclosed along with methods for their preparation. Compounds of the formula I and their salts and esters wherein Ais a CH-CH2-CH3 group are antibacterial agents. Compounds of the formula I and their salts and esters wherein A is a C=CH-CH3 group are chemical intermediates which also possess anti- bacterial activity.

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