Alkylidene pyrazolidinedione derivatives and use for...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 405/06 (2006.01) A61K 31/00 (2006.01) A61K 31/415 (2006.01) A61K 31/4152 (2006.01) A61K 31/4155 (2006.01) A61K 31/4192 (2006.01) A61P 3/10 (2006.01) A61P 15/08 (2006.01) C07D 231/32 (2006.01) C07D 401/06 (2006.01) C07D 401/10 (2006.01) C07D 403/06 (2006.01) C07D 409/06 (2006.01) C07D 409/14 (2006.01) C07D 417/06 (2006.01)

Patent

CA 2449212

The present invention is related to the use of alkylidene pyrazolidinedione derivatives of formula (I) for the treatment and/or prevention of diabetes type I and/or II, impaired glucose tolerance, insulin resistance, hyperglycemia, obesity and polycystic ovary syndrome (PCOS). In particular, the present invention is related to the use of alkylidene pyrazolidinedione derivatives of formula (I) to modulate, notably to inhibit the activity of PTPs, in particular PTP1B, TC-PTP, SHP and GLEPP-1. The present invention is furthermore related to novel alkylidene pyrazolidinedione derivatives. (I) R1 and R2 represent independently from each other an unsubstituted or substituted aryl or heteroaryl.

La présente invention concerne l'utilisation de dérivés d'alkylidène pyrazolidinedione de formule (I) pour le traitement et/ou la prévention du diabète de type I et/ou II, de la tolérance altérée au glucose, de la résistance à l'insuline, de l'hyperglycémie, de l'obésité et du syndrome des ovaires polykystiques. En particulier, la présente invention concerne l'utilisation de dérivés d'alkylidène pyrazolidinedione de formule (I) pour la modulation, notamment l'inhibition de l'activité des protéines thyrosine phosphatases (PTP), en particulier la PTP1B, la TC-PTP, la SHP, et la GLEPP-1. La présente invention concerne en outre les nouveaux dérivés d'alkylidène pyrazolidinedione de formule (I) dans laquelle R<1> et R<2> représentent indépendamment l'un de l'autre un aryle ou un hétéroaryle substitué ou non substitué.

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