Alkylthio pyrimidines as crth2 antagonists

Details Alkylthio pyrimidines as crth2 antagonists Alkylthio pyrimidines as crth2 antagonists

C - Chemistry, Metallurgy

07

D

C07D 239/38 (2006.01) A61K 31/505 (2006.01) A61P 29/00 (2006.01) C07D 239/47 (2006.01) C07D 239/58 (2006.01)

Patent

CA 2700524

Provided herein are alkylthio substituted pyrimidinc compounds having CRTH2 (G- protein-coupled chemoattractant receptor, expressed on Th2 cells) antagonistic activity, useful for the treatment or prophylaxis of diseases associated with CRTH2 activity, including the treatment of allergic diseases, eosinophil- related diseases and basophil-related diseases.

L'invention concerne des composés de pyrimidine à substitution alkylthio possédant une activité antagoniste de CRTH2 (récepteur à fonction chimio-attractive couplé à la protéine G, exprimé sur des cellules TH2), utiles pour le traitement ou la prophylaxie de maladies associées à une activité CRTH2, comprenant le traitement de maladies allergiques, de maladies à éosinophiles et de maladies à basophiles.

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