Alkylthioalkyl-isoxanzoles and -isoxazolines

C - Chemistry – Metallurgy – 07 – D

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260/311.9

C07D 261/02 (2006.01) C07D 261/04 (2006.01) C07D 261/08 (2006.01) C07D 261/18 (2006.01)

Patent

CA 1134837

CONL-42 ALKYLTHIOALKYL-ISOXAZOLES AND -ISOXAZOLINES Abstract of the Disclosure Compounds of the formula 1 Image 1 in which the dotted line represents an optional double bond, R1 is lower alkyl, COOH, COO(lower alkyl), CONH2, CON(lower alkyl)2, CN, CH2OH, CH2OSO2(lower alkyl), CH2O(lower alkyl), or CH2S(lower alkyl), R2 is H, H2, or lower alkyl, R3 is H or S(lower alkyl), R4 and R5 are the same or different and each is H, lower alkyl, S(lower alkyl), COOH, or COO(lower alkyl), and the sulfoxides and sul- fones of the above compounds as well as their pharmaceutically acceptable salts. The compounds possess anti-inflammatory, analgesic, and anti-pyretic properties, and methods for their preparation and use are also disclosed.

337066

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