Alkylthiophenoxyalkylamines

Details Alkylthiophenoxyalkylamines Alkylthiophenoxyalkylamines

A - Human Necessities

61

K

260/604.6

A61K 31/135 (2006.01) A61K 31/00 (2006.01) A61K 31/10 (2006.01) A61K 31/13 (2006.01)

Patent

CA 1125312

ALKYLTHIOPHENOXYALKYLAMINES Abstract of the Disclosure A new class of alkylthiophenoxyalkylamine derivatives and methods for preparation are described. The compounds have vaso- dilating and antispasmodic activity, inhibit blood platelet aggre- gation and are substantially free of beta-adrenergic blocking effects. They are particularly valuable in the treatment of disease states responsive to vasodilation such as obstructive peripheral vascular diseases and cerebral vascular deficiencies. Representative and preferred embodiments of the invention are N-[3-[4-(methylthio)- phenoxy]propyl]octylamine and N-[3-[4-(1-methylethyl)thio]phenoxy]- propyl]octylamine.

330146

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