A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/211, 167/240
A61K 31/395 (2006.01)
Patent
CA 1185181
Abstract of the Disclosure The invention relates to pharmaceutical compositions comprising an alkylurea of formula Image wherein Y represents R or a radical Image in which n1 and n2 denote integers from 3 to 9 and ? denotes 0 or 1, R represents a straight-chain, branched, cyclic, saturated or unsaturated aliphatic hydro- carbon radical with up to 20 carbon atoms, which is optionally substituted by halogen, hydroxyl, alkoxy, alkoxycarbonyl or optionally substituted aryl, R1 represents hydrogen or lower alkyl, R2 represents lower alkyl and R3, R4 and R5 are identical or different and each represent hydrogen, halogen, hydroxyl, cyano, lower alkyl, lower alkoxy, lower alkoxycarbonyl, lower alkylmercapto, lower alkylsulphonyl, lower alkylsulphinyl, lower alkylcarbonyl, optionally substi- tuted aryl or optionally substituted aryloxy, X denotes oxygen or sulphur and A represents one of the following radicals Image in which R' and R" arc identical or different and each denote hydrogen or lower alkyl, R''' denotes lower alkyl and m denotes 0, 1 or 2, provided that (A) if (i) X represents oxygen, (ii) A is other Image and (iii) R represents straight chain, branched or cyclic alkyl or alkenyl with 6 to 18 carbon atoms, the said alkyl or alkenyl groups optionally being sub- stituted by chlorine, bromine, fluorine or alkoxy with 1 to 4 carbon atoms, or by phenyl, then R1 is not hydrogen, methyl or ethyl; and (B) if (i) Y is other than R and (ii) X is 0, then R1 is not hydrogen; which alkylurea is in admixture with a suitable diluent or carrier. The alkylureas are useful hypolipacmic agents.
443986
Kabbe Hans-Joachim
Krause Hans-Peter
Sitt Rudiger
Aktiengesellschaft Bayer
Fetherstonhaugh & Co.
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