Alkyne matrix metalloproteinase inhibitors

Details Alkyne matrix metalloproteinase inhibitors Alkyne matrix metalloproteinase inhibitors

C - Chemistry, Metallurgy

07

C

C07C 317/44 (2006.01) A61K 31/166 (2006.01) A61K 31/18 (2006.01) A61K 31/277 (2006.01) A61K 31/4192 (2006.01) A61K 31/4196 (2006.01) A61K 31/4409 (2006.01) A61P 19/02 (2006.01) A61P 29/00 (2006.01) C07C 233/87 (2006.01) C07C 255/60 (2006.01) C07C 311/46 (2006.01) C07D 213/40 (2006.01) C07D 213/56 (2006.01) C07D 213/81 (2006.01) C07D 249/04 (2006.01) C07D 249/08 (2006.01) C07D 285/24 (2006.01)

Patent

CA 2462442

A compound of Formula (I) or a pharmaceutical acceptable salt thereof, or a tautomer thereof, wherein G1, G2, and B are as defined in the application, are selective inhibitors of MMP-13. The compounds are useful for treating diseases mediated by MMP-13, including cancer and arthritis.

L'invention concerne un composé représenté par la formule (I), y compris un sel pharmaceutiquement acceptable ou un tautomère correspondant. Les symboles de ladite formule, G¿1?, G¿2? et B, sont tels que définis dans la description. Ce type de composé, qui agit comme un inhibiteur sélectif vis-à-vis de la MMP-13, est utile pour le traitement des maladies dont la médiation est assurée par la MMP-13, y compris le cancer et l'arthrite.

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