C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/06 (2006.01) A61K 31/506 (2006.01) A61P 11/00 (2006.01) A61P 19/02 (2006.01) A61P 35/00 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01)
Patent
CA 2656535
The present invention comprises a new class of compounds capable of modulating the c-kit receptor and, accordingly, useful for treatment of c-kit mediated diseases, including various inflammatory, fibrotic and/or mast cell mediated diseases such as mastocytosis. The compounds have a general Formula (I) wherein A1-3, R1 and R3-6 are defined herein. The invention further comprises pharmaceutical compositions, methods for treatment of c-kit mediated diseases, and intermediates and processes useful for the preparation of compounds of the invention.
L'invention concerne une nouvelle classe de composés capables de moduler le récpteur c-kit, qui sont par conséquent utilisés dans le traitement de maladies médiées par c-kit, y compris diverses maladies inflammatoires, fibrotiques et/ou médiées par les mastocytes, telle la mastocytose. Les composés de l'invention répondent à la formule générale I, dans laquelle A1-3, R1 et R3-6 sont tels que définis dans la description. L'invention porte en outre sur des compositions pharmaceutiques, des procédés de traitement de maladies médiées par c-kit, et sur des intermédiaires et procédés utilisés dans la préparation des composés précités.
White Ryan
Amgen Inc.
Gowling Lafleur Henderson Llp
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