Alkynols and process for their preparation

Details Alkynols and process for their preparation Alkynols and process for their preparation

C - Chemistry, Metallurgy

07

C

260/627.1, 260/3

C07C 33/04 (2006.01) C07D 309/12 (2006.01)

Patent

CA 1084516

ABSTRACT OF THE DISCLOSURE Alkynols of the formula, Image wherain X ia F, Cl or Br; n is 0 or 1; m is 0 or 1 and R (if m is 0) is hydroxyalkyl of 1-6 carbon atoms or (if m is 1) alkyl, straight-chain hydroxy alkyl or straight-chain tetrahydropyran- 2-yloxyalkyl of 2-6 carbon atoms in the alkyl, have anti- inflammatory activity. These compounda may be prepared by solvolyzing reactions on compounds of tho following formula (II) Image wherein Q is an functionally-modified hydroxyl and Z is alkyl of 1-6 carbon atoms in the alkyl, substituted by 0, when m is 0, or is alkyl or alkyl substituted by 0, each of 2-6 carbon atoms in the alkyl, when m is 1, wlth a solvolyzing agent.

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