Alkynyl compounds as non-nucleoside reverse transcriptase...

Details Alkynyl compounds as non-nucleoside reverse transcriptase... Alkynyl compounds as non-nucleoside reverse transcriptase...

C - Chemistry, Metallurgy

07

D

C07D 307/33 (2006.01) A61K 31/167 (2006.01) A61K 31/192 (2006.01) A61K 31/365 (2006.01) A61K 31/445 (2006.01) A61K 31/5375 (2006.01) A61P 31/18 (2006.01) C07C 235/24 (2006.01) C07D 213/89 (2006.01) C07D 265/30 (2006.01) C07D 405/06 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2577144

Compounds of formula (I): (see formula I) wherein Q, R1, R2, R3, R4, R6 and R7 are as defined herein. The compounds are useful as reverse transcriptase inhibitors against HIV. In particular, the compounds are active against wild type and single or double mutant strains of HIV.

La présente invention concerne des composés représentés par la formule (I) dans laquelle Q, R1, R2, R3, R4, R6 et R7 sont tels que définis dans les spécifications. Ces composés conviennent comme inhibiteurs de transcriptase inverse contre le VIH. Ces composés sont actifs, en particulier, contre des souches mutantes simple brin ou double brin de type sauvage du VIH.

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