Alkynyl containing hydroxamic acid compounds as tace inhibitors

Details Alkynyl containing hydroxamic acid compounds as tace inhibitors Alkynyl containing hydroxamic acid compounds as tace inhibitors

C - Chemistry, Metallurgy

07

C

C07C 317/44 (2006.01) A61K 31/16 (2006.01) A61P 19/02 (2006.01) A61P 37/00 (2006.01) C07C 259/06 (2006.01) C07C 323/60 (2006.01) C07D 207/34 (2006.01) C07D 209/18 (2006.01) C07D 209/48 (2006.01) C07D 211/34 (2006.01) C07D 213/56 (2006.01) C07D 215/48 (2006.01) C07D 215/54 (2006.01) C07D 217/06 (2006.01) C07D 217/26 (2006.01) C07D 295/08 (2006.01) C07D 295/092 (2006.01) C07D 309/04 (2006.01) C07D 311/84 (2006.01) C07D 333/24 (2006.01) C07D 333/60 (2006.01) C07D 333/68 (2006.01) C07D 335/02 (2006.01) C07D 335

Patent

CA 2356346

The invention concerns compounds of formula (I) which are useful in treating disease conditions mediated by TNF-.alpha., such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss.

L'invention concerne des composés représentés par la formule (I), qui sont utiles pour traiter des affections dans lesquelles intervient TNF-.alpha. telles que la polyarthrite rhumatoïde, l'ostéoarthrite, la septicémie, le SIDA, la rectocolite hémorragique, la sclérose en plaques, la maladie de Crohn et la dégénérescence de cartilage.

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