Alkynyl derivatives as modulators of metabotropic glutamate...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 277/22 (2006.01) A61K 31/422 (2006.01) A61K 31/47 (2006.01) A61K 31/4709 (2006.01) C07D 213/56 (2006.01) C07D 215/06 (2006.01) C07D 233/54 (2006.01) C07D 239/26 (2006.01) C07D 263/56 (2006.01) C07D 401/06 (2006.01) C07D 403/06 (2006.01) C07D 413/06 (2006.01) C07D 417/06 (2006.01) C07D 471/04 (2006.01) C07D 498/04 (2006.01)

Patent

CA 2570987

The present invention relates to novel compounds of formula (I) wherein W, n, X and W~ are defined in the description; invention compounds are modulators of metabotropic glutamate receptors - subtype 5 (~mGluR5~) which are useful for the treatment of central nervous system disorders as well as other disorders modulated by mGluR5 receptors.

La présente invention concerne des nouveaux composés de formule (I), W, n, X et W' ayant les significations données dans le descriptif. L'invention concerne également des modulateurs de récepteurs de glutamate métabotropiques du sous-type 5 ( mGluR5 ), servant au traitement de troubles du système nerveux central ainsi que d'autres troubles modulés par des récepteurs de mGluR5.

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