Alkynyl-substituted quinolin-2-one derivatives useful as...

Details Alkynyl-substituted quinolin-2-one derivatives useful as... Alkynyl-substituted quinolin-2-one derivatives useful as...

C - Chemistry, Metallurgy

07

D

C07D 401/06 (2006.01) A61K 31/47 (2006.01) C07D 215/22 (2006.01) C07D 401/10 (2006.01) C07D 401/14 (2006.01) C07F 7/08 (2006.01) C07F 7/18 (2006.01)

Patent

CA 2341690

The present invention relates to compounds of formula (1) and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, and R11 are as defined herein. The above compounds of formula (1) are useful in the treatment of hyperproliferative disorders, such as cancer, in mammals. The invention also relates to pharmaceutical compositions containing the compounds of formula (1) and to methods of inhibiting abnormal cell growth, including cancer, in a mammal by administering the compounds of formula (1) to a mammal requiring such treatment.

L'invention concerne des composés correspondant à la formule (1), des sels, promédicaments et solvates de ceux-ci, acceptables sur le plan pharmacologique. Dans cette formule, R<1>, R<2>, R<3>, R<4>, R<5>, R<6>, R<7>, R<8>, R<9>, R<10> et R<11> possèdent les notations données dans la description. Ces composés correspondant à la formule (1) sont utiles, chez les mammifères, dans le traitement de troubles extrêmement prolifératifs, tels que le cancer. L'invention concerne également des compositions pharmaceutiques contenant les composés correspondant à la formule (1), ainsi que des méthodes destinées à inhiber chez un mammifère la croissance cellulaire anormale, notamment le cancer, et consistant à administrer lesdits composés au mammifère nécessitant un tel traitement.

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