Alkynyl-substituted quinolin-2-one derivatives useful as...

Details Alkynyl-substituted quinolin-2-one derivatives useful as... Alkynyl-substituted quinolin-2-one derivatives useful as...

C - Chemistry, Metallurgy

07

D

C07D 215/22 (2006.01) C07D 401/06 (2006.01) C07D 401/10 (2006.01) C07D 401/14 (2006.01) C07F 7/08 (2006.01)

Patent

CA 2578326

The present invention relates to compounds of formula 28 (see above formula) wherein R1, R2, R3, R4, R5, R6, R7, R10 and R11 are as defined herein. The above compounds are useful as intermediates of alkynyl-substituted quinolin-2-one derivatives for treating hyperproliferative diseases, such as cancer, in mammals.

La présente invention concerne des composés de la formule 28 (voir formule ci-dessus) dans laquelle R1, R2, R3, R4, R5, R6, R7, R10 et R11 sont tels que définis ici. Les composés ci-dessus sont utiles comme dérivés de quinoléin-2-one à substitution alcynyle pour traiter des maladies hyperprolifératifs, tels que le cancer, chez les mammifères.

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