C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01)
Patent
CA 2708420
The invention relates to alkynylaryl compounds according to the general formula (I) in which A, B, D, E, R a, R1, R3, R4, R5 and q are as defined in the claims, and salts, N-oxides, solvates and prodrugs thereof, to pharmaceutical compositions comprising said alkynylaryl compounds, to methods of preparing said alkynylaryl compounds, to intermediate compounds useful in said methods, to uses of said intermediate compounds in the preparation of said alkynylaryl compounds, as well as to uses of said alkynylaryl compounds for manufacturing a pharmaceutical composition for the treatment of diseases of dysregulated vascular growth or of diseases which are accompanied with dysregulated vascular growth.
L'invention concerne des composés d'alcynylaryle de formule générale (I), dans laquelle A, B, D, E, Ra, R1, R3, R4, R5 et q sont tels que définis dans les revendications, ainsi que leurs sels, N-oxydes, solvates et promédicaments. L'invention concerne également des compositions pharmaceutiques comprenant lesdits composés d'alcynylaryle, des procédés de préparation desdits composés d'alcynylaryle, des composés intermédiaires utiles pour lesdits procédé, des utilisations desdits composés intermédiaires pour la préparation desdits composés d'alcynylaryle, ainsi que des utilisations desdits composés d'alcynylaryle pour la fabrication d'une composition pharmaceutique pour le traitement de maladies relatives à une croissance vasculaire déréglée ou de maladies qui sont accompagnées d'une croissance vasculaire déréglée.
Boemer Ulf
Briem Hans
Hartung Ingo
Kettschau Georg
Thierauch Karl-Heinz
Bayer Schering Pharma Aktiengesellschaft
Fetherstonhaugh & Co.
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