C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 239/48 (2006.01) A61K 31/495 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) C07D 401/06 (2006.01) C07D 403/06 (2006.01)
Patent
CA 2689393
The invention relates to alkynylpyrimidines according to the general formula (I) in which A, R1, R2, R3, R4, R5, and R6 are as defined in the claims, to pharmaceutical compositions comprising said alkynylpyrimidines, to methods of preparing said alkynylpyrimidines, as well as to uses thereof for manufacturing a pharmaceutical composition for the treatment of diseases of dysregulated vascular growth or of diseases which are accompanied with dysregulated vascular growth, wherein the compounds effectively interfere with Tie2 and VEGFR2 signalling.
La présente invention concerne des alcynylpyrimidines selon la formule générale (I) : dans laquelle A, R1, R2, R3, R4, R5, et R6 sont définis tels que dans les revendications. L'invention concerne également les compositions pharmaceutiques comprenant lesdites alcynylpyrimidines, les procédés de préparation desdites alcynylpyrimidines, et les utilisations desdites dans la préparation d'une composition pharmaceutique pour le traitement des maladies de croissance vasculaire mal régulée, ou de maladies accompagnées de croissance vasculaire mal régulée, lesdits composés interférant efficacement avec la signalisation de Tie2 et de VEGFR2.
Boemer Ulf
Bothe Ulrich
Hartung Ingo
Kettschau Georg
Krueger Martin
Bayer Schering Pharma Aktiengesellschaft
Marks & Clerk
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