Allenic aryl sulfonamide hydroxamic acids as matrix...

Details Allenic aryl sulfonamide hydroxamic acids as matrix... Allenic aryl sulfonamide hydroxamic acids as matrix...

C - Chemistry, Metallurgy

07

C

C07C 311/29 (2006.01) A61K 31/48 (2006.01) A61K 31/54 (2006.01) A61K 31/5513 (2006.01) A61P 19/02 (2006.01) C07C 29/38 (2006.01) C07C 309/87 (2006.01) C07D 243/14 (2006.01) C07D 279/12 (2006.01)

Patent

CA 2464727

Compounds of the formula (I) are useful in treating disease conditions mediated by TNF-.alpha., such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease, degenerative cartilage loss, graft rejection, cachexia, inflammation, fever, insulin resistance, septic shock, congestive heart failure, inflammatory disease of the central nervous system, inflammatory bowel disease and HIV.

L'invention concerne des composés de formule (I) utiles pour le traitement de maladies sous la dépendance du TNF-.alpha., telles que l'arthrite rhumatoïde, l'ostéoarthrite, la sepsie, le SIDA, la colite ulcéreuse, la sclérose multiple, la maladie de Crohn, la perte de cartilage dégénérative, le rejet de greffe, la cachexie, l'inflammation, la fièvre, l'insulinorésistance, le choc septique, l'insuffisance cardiaque globale, l'inflammation du SNC, la maladie intestinale inflammatoire et le VIH.

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