Allenic prostacyclins

Details Allenic prostacyclins Allenic prostacyclins

C - Chemistry, Metallurgy

07

C

260/235.01

C07C 405/00 (2006.01)

Patent

CA 1252781

Abstract The present invention describes allenic prostacyclin derivatives of the formula: Image wherein: n is 0, 1,2 R1 is hydrogen or lower alkyl; R2 is hydrogen, lower alkyl, cycloalkyl, hetereoalkyl, halogen, aryl, alkylthio, arylthio, alkylsulfinyl, arylsulfinyl or trifluoromethyl; R3 is a lower alkyl, a cycloalkyl, a cycloheteroalkyl, a lower alkyl having one or more fluorines or containing 1 or 2 unsaturated bonds; carbon 15 may be in the R or the S configuration, or a mixture of R and S. These compounds are useful for the treatment of platelet dysfunction, atherosclerosis, allergic disorders, gastric ulcers, hypertension and tumor cell metastasis. Also disclosed is the process for preparing them and the appropriate intermediates.

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