Allergen mutants

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/29 (2006.01) A61K 39/36 (2006.01) A61P 37/08 (2006.01) C07K 14/415 (2006.01) C12P 21/02 (2006.01) C40B 10/00 (2006.01) C40B 50/06 (2006.01) G01N 33/564 (2006.01)

Patent

CA 2486112

Novel recombinant allergens with multiple mutations and reduced IgE binding affinity are disclosed. The allergens are mutants of naturally occurring allergens. The overall .alpha.-carbon backbone tertiary structure is essentially preserved. Also disclosed is a method for preparing such recombinant allergens as well as uses thereof.

L'invention concerne de nouveaux allergènes recombinants qui présentent de multiples mutations et une faible affinité de liaison aux IgE. Ces allergènes sont des mutants d'allergènes naturels. La structure tertiaire carbone alpha générale est essentiellement préservée. L'invention concerne également une méthode de préparation de ces allergènes recombinants ainsi que leurs utilisations.

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