C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/29 (2006.01) A61K 38/10 (2006.01) A61K 38/16 (2006.01) A61K 39/36 (2006.01) C07K 5/00 (2006.01) C07K 5/08 (2006.01) C07K 5/10 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/00 (2006.01) C07K 14/415 (2006.01) C07K 16/16 (2006.01) C12N 15/09 (2006.01) C12N 15/12 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01) C12P 21/08 (2006.01) C12Q 1/02 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01) G01N 33/68 (2006.01) A61K 39/395 (2006.01)
Patent
CA 2120954
2120954 9401560 PCTABS00030 The present invention provides isolated peptides of Japanese cedar pollen protein allergen, Cry j I. Peptides within the scope of the invention comprise at least one T cell epitope, or preferably at least two T cell epitopes of Cry j I. The invention also pertains to modified peptides having similar or enhanced therapeutic properties as the corresponding, naturally-occurring allergen or portion thereof, but having reduced side effects. The invention further provides nucleic acid sequences coding for peptides of the invention. Methods of treatment or of diagnosis of sensitivity to Japanese cedar pollens in an individual and therapeutic compositions comprising one or more peptides of the invention are also provided. The present invention also provides Jun v I and Jun s I protein allergens and nucleic acid sequences coding for Jun s I and Jun v I allergens. Jun s I and Jun v I are protein allergens which are immunologically cross-reactive with Cry j I.
Bond Julian F.
Garman Richard D.
Griffith Irwin J.
Kuo Meichang
Pollock Joanne
Immulogic Pharmaceutical Corporation
Smart & Biggar
LandOfFree
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