Allergy inhibitor compositions and kits and methods of using...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/86 (2006.01)

Patent

CA 2631467

Compositions and kits for inhibiting an allergic response against an allergenic protein are disclosed. The compositions comprise a eukaryotic cell expression vector containing nucleotide sequences encoding an allergenic protein or a polypeptide that comprises an antigenic epitope of said allergenic protein; and an allergenic protein or a polypeptide that comprises an antigenic epitope of the allergenic protein. The kits comprise a first container which comprises a eukaryotic cell expression vector containing nucleotide sequences encoding an allergenic protein or a polypeptide that comprises an antigenic epitope of the allergenic protein and a second container which comprises an allergenic protein or a polypeptide that comprises an antigenic epitope of said allergenic protein. Compositions and kits for inhibiting an allergic response against an flea allergenic protein; a feline allergenic protein; a canine allergenic protein; a dust mite allergenic protein; a peanut allergenic protein; a Japanese cedar allergenic protein; and a blomia tropicalis allergenic protein are disclosed. Methods if using such compositions and kits are also disclosed.

La présente invention concerne des compositions et des kits d'inhibition d'une réponse allergique contre une protéine allergène. Les compositions comprennent un vecteur d~expression de cellule eucaryote contenant des séquences nucléotidiques encodant une protéine allergène ou un polypeptide qui comprennent un épitope antigène de ladite protéine allergène, ainsi qu~une protéine allergène ou un polypeptide qui comprennent un épitope de la protéine allergène. Les kits comprennent un premier récipient qui comprend un vecteur d~expression de cellule eucaryote contenant des séquences nucléotidiques encodant une protéine allergène ou un polypeptide qui comprend un épitope antigène de ladite protéine allergène ainsi qu~un second récipient qui comprend une protéine allergène ou un polypeptide qui comprend un épitope antigène de ladite protéine allergène. Les compositions et les kits d~inhibition d~une réponse allergique contre une protéine allergène de puce, une de félin, une de chien, une d'acare, une de cacahuète, une de cèdre japonais et une de blomia tropicalis. Des procédés utilisant de tels compositions et kits sont également indiqués.

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