Allergy treatment by epicutaneous allergen administration

Details Allergy treatment by epicutaneous allergen administration Allergy treatment by epicutaneous allergen administration

A - Human Necessities

61

B

A61B 10/00 (2006.01) A61K 39/35 (2006.01)

Patent

CA 2630840

The invention provides pharmaceutical compositions, kits, and methods for the treatment of allergy. The compositions are adapted for epicutaneous administration and comprise an allergen and at least one pharmaceutically acceptable excipient. They may be designed as adhesive patches, intradermal delivery devices, ointments, gels, sprays, or similar types of formulation suitable for administration to the skin. Furthermore, the invention provides the use of such compositions in the treatment of allergy. In particular, the compositions are administered to pre-treated skin, wherein the pre-treatment comprises partial or complete dekeratinisation of the epidermis at the selected site of administration.

La présente invention concerne des préparations pharmaceutiques, des kits et des méthodes pour le traitement d~une allergie. Les préparations sont adaptées à une administration épicutanée et comprennent un allergène et au moins un excipient de qualité pharmaceutique. Les préparations peuvent être sous forme de timbres adhésifs, de dispositifs de libération intra-cutanée, d'onguents, de gels, de vaporisations ou de types de formule similaires et adaptés à une administration cutanée. En outre, la présente invention concerne l'emploi de telles préparations dans le traitement d~une allergie. En particulier, les préparations sont administrées sur une peau prétraitée, le prétraitement se composant d'une dékératinisation partielle ou totale de l'épiderme au niveau du site d'administration choisi.

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