C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 21/08 (2006.01) A61K 39/395 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01) C12N 5/18 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2119128
Disclosed are methods for the alleviation of symptoms associated with inflammatory disease states, and more particularly to the inhibition of inflammatory processes associated with the multiple sclerosis disease, by administering a pharmaceutically effective amount of antibody substance immunologically reactive with the common .beta. chain (CD18) of human leukocyte integrins and/or competes with mAb 60.3 for binding to human LFA-1.
On décrit des méthodes permettant d'alléger les symptômes associés à des états inflammatoires dûs aux maladies, et plus particulièrement l'inhibition de processus inflammatoires liés à la sclérose en plaques. Lesdites méthodes consistent à administrer une quantité pharmaceutiquement efficace d'une substance d'anticorps qui réagit de manière immunologique avec la chaîne beta commune (CD18) d'intégrines de leucocytes et/ou entrent en compétition avec le mAb 60.3 pour se lier au LFA-1.
Icos Corporation
Smart & Biggar
The Board Of Regents Of The University Of Washington
LandOfFree
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