Allogeneic vaccine and methods to synthesize same

Details Allogeneic vaccine and methods to synthesize same Allogeneic vaccine and methods to synthesize same

C - Chemistry, Metallurgy

12

N

C12N 5/10 (2006.01) A61K 35/12 (2006.01) A61P 35/00 (2006.01) C12N 15/23 (2006.01) C12N 15/26 (2006.01) C12N 15/867 (2006.01)

Patent

CA 2156273

This invention provides a retroviral vector comprising (a) a 3'LTR; and (b) an insert having (i) a promoter, (ii) a sequence encoding an immunomolecule selected from the group consisting of cytokines, adhesion molecules, costimulatory factors, tumor associated antigens and tumor specific antigens, and (iii) a poly A signal, respectively, said promoter, sequence encoding an immunomolecule and poly A signal being aligned in a 5' to 3' orientation, wherein the insert is positioned within the 3'LTR in the orientation opposite to that of the 3'LTR. This invention further provides a genetically manipulated cell useful for treating or preventing a malignant tumor in a patient which a) expresses at least one immunomolecule selected from the group consisting of cytokines, adhesion molecules, costimulatory factors, tumor associated antigens and tumor specific antigens; and b) is allogenic to the patient.

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