A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/00 (2006.01) A61K 39/39 (2006.01) A61P 35/00 (2006.01) C12N 5/10 (2006.01) C12N 15/864 (2006.01)
Patent
CA 2466530
The invention relates to the use of a tumor cell for producing a vaccine for the treatment or prophylaxis of tumors in patients, said tumor cell expressing a costimulatory polypeptide and said tumor cell and said patient having non- identical MHC molecules. The invention further relates to the use of a costimulatory polypeptide-expressing tumor cell for producing a vaccine for increasing the lytic activity of NK cells in the treatment or prophylaxis of a tumor in a patient that is allogenic with respect to the tumor cell.
L'invention concerne l'utilisation d'une cellule tumorale pour préparer un vaccin destiné au traitement thérapeutique ou prophylactique de tumeurs chez des patients, ladite cellule tumorale exprimant un polypeptide co-stimulant et les molécules MHC de cette cellule tumorale et du patient ne correspondant pas. La présente invention porte également sur l'utilisation d'une cellule tumorale exprimant un polypeptide co-stimulant pour préparer un vaccin destiné à augmenter l'activité lytique de cellules NK lors du traitement thérapeutique ou prophylactique d'une tumeur chez un patient allogénique relativement à ladite cellule tumorale.
Bogedain Christoph
Breidenstein Claudia
Dinkel Adelheid
Moebius Ulrich
Nieland John
Mbm Intellectual Property Law Llp
Medigene Aktiengesellschaft
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