Allograft of reduced immunogenicity and method and reagent...

Details Allograft of reduced immunogenicity and method and reagent... Allograft of reduced immunogenicity and method and reagent...

A - Human Necessities

61

K

167/129, 167/322

A61K 39/00 (2006.01) A01N 1/02 (2006.01) A61K 47/48 (2006.01) C07K 17/06 (2006.01)

Patent

CA 1221030

ABSTRACT OF THE DISCLOSURE Allograft survival is enhanced by pretreat- ing the allograft with an immunotoxin against an Ia equivalent antigen borne by the allograft to deplete the allograft of cells that bear the antigen thereby reducing the ability of the allograft to stimulate an immune response from the recipient of the allograft.

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