Allosteric adenosine receptor modulators

Details Allosteric adenosine receptor modulators Allosteric adenosine receptor modulators

A - Human Necessities

61

K

A61K 31/505 (2006.01) A61K 31/381 (2006.01) A61K 31/382 (2006.01) A61K 31/4365 (2006.01) A61K 31/519 (2006.01) A61P 3/10 (2006.01) A61P 9/06 (2006.01) A61P 9/10 (2006.01) A61P 27/06 (2006.01) C07D 333/36 (2006.01) C07D 333/66 (2006.01) C07D 333/78 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2302396

The present invention relates to compounds of formulas (IA, IB and IC), the preparation thereof, pharmaceutical formulations thereof, and their use in medicine as allosteric adenosine receptor modulators for uses including protection against hypoxia and ischemia induced injury and treatment of adenosine-sensitive cardiac arrhythmias.

L'invention concerne des composés de formule (IA, IB et IC), ainsi que leur préparation, des formulations pharmaceutiques les contenant et leur utilisation médicale en tant que modulateurs allostériques des récepteurs de l'adénosine, notamment pour prévenir la formation de lésions d'origine ischémique et hypoxique et pour les arythmies cardiaques sensibles à l'adénosine.

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