Allosteric modulation of ship polypeptides and uses thereof

Details Allosteric modulation of ship polypeptides and uses thereof Allosteric modulation of ship polypeptides and uses thereof

G - Physics

01

N

G01N 33/573 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2671618

The invention provides a method for identifying allosteric modulators of a SHIP polypeptide, wherein said SHIP polypeptide is contacted with a test compound, and wherein said SHIP polypeptide comprises an allosteric site selected from the group consisting of a SHIP C2 domain and a SHIP PH domain.

L'invention concerne un procédé d'identification de modulateurs allostériques d'un polypeptide SHIP, ledit polypeptide SHIP étant en contact avec un composé de test, et ledit polypeptide SHIP comprenant un site allostérique choisi dans le groupe constitué par un domaine SHIP C2 et un domaine SHIP PH.

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