Allosteric modulators of the nmda receptor

Details Allosteric modulators of the nmda receptor Allosteric modulators of the nmda receptor

A - Human Necessities

61

K

A61K 38/04 (2006.01) C07K 14/435 (2006.01)

Patent

CA 2202513

Novel compounds and compositions for modulating NMDA receptor function comprising Conantokin-G and derivatives thereof; methods for modulating NMDA receptor function and methods for treating neuropsychopharmacological disorders, using the novel compounds and compositions of the invention; and a method for screening compounds capable of binding to a novel allosteric modulatory site, are described.

L'invention se rapporte à de nouveaux composés et compositions destinés à moduler la fonction du récepteur de NMDA et comprenant la Conantokine-G et des dérivés de celle-ci; à des procédés de modulation de la fonction du récepteur de NMDA et à des procédés de traitement des troubles neuropsychopharmacologiques et d'utilisation de ces nouvelles compositions, ainsi qu'à un procédé de criblage de composés capables de se fixer à un nouveau site modulateur allostérique.

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