Allylamides useful in the treatment of alzheimer's disease

Details Allylamides useful in the treatment of alzheimer's disease Allylamides useful in the treatment of alzheimer's disease

A - Human Necessities

61

K

A61K 31/47 (2006.01) A61K 31/195 (2006.01) A61K 31/401 (2006.01) A61K 31/495 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2462875

Disclosed are methods for treating Alzheimer's disease, and other diseases, and/or inhibiting beta-secretase enzyme, and/or inhibiting deposition of A beta peptide in a mammal, by use of compounds of formula (I) where R1, R2, R3, B, Jl, J2, X and Z are as defined herein.

L'invention concerne des méthodes permettant de traiter la maladie d'Alzheimer et d'autres maladies, et/ou d'inhiber l'enzyme bêta-sécrétase, et/ou d'inhiber le dépôt de peptide bêta A chez un mammifère, par l'utilisation de composés de formule (I), dans laquelle R¿1?, R¿2?, R¿3?, B, J?1¿, J?2¿, X et Z sont tels que définis dans la description.

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