.alpha.(1,3)-galactosyltransferase null cells, methods of...

A - Human Necessities – 01 – K

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A01K 67/027 (2006.01) C12N 5/00 (2006.01) C12N 15/00 (2006.01)

Patent

CA 2507486

The invention relates to the genetic manipulation of non-human animals. More particularly, the invention relates to genetic manipulation of non-human animals to be used for xenotransplantation. The invention provides a method of selecting GGTA l null cells, a viable GGTA l null swine, methods for making such swine, and methods of using cells, tissues and organs of such swine for xenotransplantation.

La présente invention relève du domaine de la manipulation génétique d'animaux non humains et concerne en particulier la manipulation génétique d'animaux non humains destinés à être utilisés pour une xénotransplantation. Cette invention concerne un procédé de sélection de cellules dépourvues de GGTA 1, un porc viable dépourvu de GGTA 1, des procédés permettant d'obtenir ledit porc, ainsi que des procédés d'utilisation de cellules, de tissus et d'organes dudit porc pour une xénotransplantation.

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