.alpha.1, 4-galactosyltransferase and dna encoding thereof

Details .alpha.1, 4-galactosyltransferase and dna encoding thereof .alpha.1, 4-galactosyltransferase and dna encoding thereof

C - Chemistry, Metallurgy

12

N

C12N 15/54 (2006.01) C12N 5/10 (2006.01) C12N 9/10 (2006.01) C12N 15/63 (2006.01) C12P 19/58 (2006.01)

Patent

CA 2315885

The object of the present invention is to provide .alpha.1,4--galactosyltransferase to transfer a galactose residue to C4 position of galactose residue of lactosylceramide or galactosylceramide, and DNA coding for the enzyme. What is provided includes the following polypeptides (a) and (b), and DNAs encoding thereof: (a) a polypeptide consisting of an amino acid sequence represented by the amino acid Nos. 46-353 in SEQ ID NO: 2; or (b) a polypeptide which comprises an amino acid sequence including substitution, deletion, insertion or transposition of one or few amino acids in the amino acid sequence of (a) and which has an enzymatic activity to transfer a galactose residue from a galactose donor to C4 position of galactose residue of lactosylceramide or galactosylceramide which serves as an acceptor.

L'objet de la présente invention est d'obtenir un .alpha.1,4--galactosyltransférase pour transférer un résidu de galactose à position C4 du résidu de galactose de lactosylcéramide ou galactosylcéramide, ainsi que de l'ADN codant pour l'enzyme. L'invention comprend les polypeptides suivants (a) et (b), et des ADN codant pour ceux-ci : (a) un polypeptide consistant en une séquence d'acides aminés représentée par l'acide aminé nos. 46-353 en SEQ ID NO: 2; ou (b) un polypeptide qui comprend une séquence d'acides aminés comportant la substitution, la délétion, l'insertion ou la transposition d'un ou de quelques acides aminés dans la séquence d'acides aminés (a) et qui a une activité enzymatique de transfert d'un résidu de galactose à partir d'un donneur de galactose à position C4 de résidu de galactose de lactosylcéramide ou galactosylcéramide qui sert d'accepteur.

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