.alpha.1-adrenergic receptor antagonists

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 295/15 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) A61K 31/55 (2006.01) C07D 295/13 (2006.01) C07D 311/84 (2006.01) C07D 471/04 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2251016

Phenylpiperazine derivatives having a high affinity for the alpha 1-adrenergic receptor and pharmaceutical compositions containing same are disclosed. A method for the use of such derivatives to treat benign prostatic hyperplasia is also described.

Composés dérivés de la phénylpipérazine ayant une affinité élevée pour le récepteur .alpha.1- adrénergique et compositions pharmaceutiques les contenant. Également décrite est une méthode d'utilisation de tels dérivés pour traiter l'hypertension portale ou la cirrhose. Les dérivés de l'invention sont de formule générale I. Image

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