C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/277, 260/335
C07D 401/06 (2006.01) C07D 205/04 (2006.01)
Patent
CA 1103674
ABSTRACT OF THE DISCLOSURE .alpha.-(1-R-3-Azetidinyl)-.alpha.-phenyl-.alpha.-substituted-acetamides and - acetonitriles represented by the following formula: Image wherein R represents hydrogen, C1-C8 alkyl, C3-C9 cycloalkyl or phenyl C1- C8 alkyl, R1 represents phenyl or 2-pyridyl, and Y is carbamoyl or cyano having antiarrhythmic activity are disclosed. Pharmaceutically acceptable acid addition salts of the free bases and quaternary salts are included as part of the invention.
302047
Cale Albert D. Jr.
Jenkins Herndon
Robins (a.h.) Company Incorporated
Smart & Biggar
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