C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/00 (2006.01) C07K 14/705 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2419545
The present invention describes native and degenerate peptides derived from human .alpha.7 nicotinic receptor useful as minimized ligands for .beta. amyloid peptides. These peptides are useful to discover compounds that inhibit the interaction with .beta. amyloid peptides with the .alpha.7 nicotinic receptor, and are also useful in assays to measure .beta. amyloid.
La présente invention concerne des peptides natifs et dégénérés issus du récepteur nicotinique .alpha.7 humain utilisés comme ligands atténués pour les peptides amyloïdes. Ces peptides sont utilisés d'une part pour découvrir de nouveaux composés qui inhibent l'interaction entre les peptides .beta.-amyloïdes et le récepteur nicotinique .alpha.7, et d'autres part dans des dosages de mesure de .beta.-amyloïde.
Lee Daniel H. S.
Plata-Salaman Carlos
Reitz Allen B.
Wang Hoau-Yan
Lee Daniel H. S.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Ortho-Mcneil Pharmaceutical Inc.
Plata-Salaman Carlos
Reitz Allen B.
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