.alpha.-alkyl-4-amino-3-quinolinemethanols and 1-(4-...

Details .alpha.-alkyl-4-amino-3-quinolinemethanols and 1-(4-... .alpha.-alkyl-4-amino-3-quinolinemethanols and 1-(4-...

C - Chemistry, Metallurgy

07

D

167/226, 260/289

C07D 215/42 (2006.01) A61K 31/47 (2006.01)

Patent

CA 1297111

ABSTRACT HOE 86/S 005 There are described compounds of the formula Image where X is hydrogen, halogen, loweralkyl, loweralkoxy or trifluoromethyl; R is -?-R4 or -?-R4, R4 being loweralkyl; R1 is hydrogen, loweralkyl or arylloweralkyl; R2 is hydrogen, loweralkyl or arylloweralkyl; and R3 is loweralkyl, with the proviso that when R is acetyl, R3 is methyl and X is hydrogen, R1 and R2 are not both hydrogen, or pharmaceutically acceptable acid addition salts thereof, which are useful for enhancing memory and for treating Alzheimer's disease.

545157

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