C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 211/56 (2006.01) C07C 45/46 (2006.01) C07C 45/63 (2006.01) C07C 49/80 (2006.01) C07C 49/813 (2006.01) C07C 49/84 (2006.01) C07C 67/00 (2006.01) C07C 67/343 (2006.01) C07C 231/10 (2006.01) C07D 211/26 (2006.01) C07D 213/74 (2006.01) C07D 295/182 (2006.01) C07C 235/60 (2006.01)
Patent
CA 2415459
This disclosure relates to the use of .alpha.,.alpha.-dibromo-.alpha.- chloroacetophenone compounds as intermediates for the preparation of aromatic carbonyl compounds, especially aromatic amides. The compound 2,5-bis(2,2,2- trifluoroethoxy)-.alpha.,.alpha.-dibromo-.alpha.-chloro-acetophenone is especially useful as an intermediate for the preparation of flecainide, a known pharmaceutical.
La présente invention concerne l'utilisation de composés de .alpha.,.alpha.-dibromo-.alpha.-chloroacétophénone en tant qu'intermédiaires pour préparer des composés carbonyle aromatique, et plus spécifiquement des amides aromatiques. Le composé 2,5-bis(2,2,2-trifluoroéthoxy)-.alpha.,.alpha.-dibromo-.alpha.-chloro-acétophénone est tout particulièrement utile en tant qu'intermédiaire pour préparer le flécaïnide, lequel est une substance pharmaceutique connue.
Merai Shilpa V.
Patel Hiren Kumar V.
Patel Mahendra R.
Ray Anup Kumar
Fetherstonhaugh & Co.
Geneva Pharmaceuticals Inc.
Sandoz Ag
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