C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 259/04 (2006.01) A61K 31/16 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) C07C 259/06 (2006.01) C07C 259/08 (2006.01) C07C 259/10 (2006.01)
Patent
CA 2570307
Compounds of the formula (I) are described in which Z, Q, X, L, m and n assume the meanings stated in the description. The compounds (I) inhibit the production of TNF .alpha. and may thus be useful in the treatment of inflammation and pathological conditions involving overproduction of said cytokine. They furthermore exhibit significant inhibitory activity on the proliferation of tumour cells and may thus be used for the treatment and/or prevention of tumorous, neurodegenerative or autoimmune disorders.
L'invention porte sur des composés de la formule (1) dans laquelle Z, Q, X, L, m et n possèdent les significations données dans la description. Les composés (1) inhibent la production de TNF a et peuvent par conséquent être utilisés dans le traitement de l'inflammation et d'états pathologiques impliquant une surproduction de cytokine. Les composés de l'invention possèdent en outre une activité inhibitrice significative sur la prolifération des cellules tumorales et peuvent dès lors être utilisés dans le traitement et/ou la prévention d'affections tumorales, dégénératives ou auto-immunes.
Mascagni Paolo
Mazzaferro Rocco
Pinori Massimo
Italfarmaco Spa
Riches Mckenzie & Herbert Llp
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