.alpha.-amino sulfonyl hydroxamic acids as matrix...

Details .alpha.-amino sulfonyl hydroxamic acids as matrix... .alpha.-amino sulfonyl hydroxamic acids as matrix...

C - Chemistry, Metallurgy

07

D

C07D 209/20 (2006.01) A61K 31/40 (2006.01) C07C 311/19 (2006.01) C07C 311/29 (2006.01)

Patent

CA 2268418

A compound of formula (I) or pharmaceutical acceptable salts thereof, wherein R1 is isopropyl, 2-methylbut-2-yl, phenyl, benzyl, or 1H-indol-3ylmethyl; R2 is n-octyl, phenyl, or phenyl substituted with methoxy, fluoro, or bromo, are matrix metalloproteinase inhibitors.

Composé représenté par la formule (I) ou ses sels acceptables sur le plan pharmaceutique; I dans laquelle R1 représente isopropyle, 2-méthylbut-2yle, phényle, benzyle ou 1H-indol-3ylméthyle; R2 représente n-octyle, phényle ou phényle substitué par méthoxy, fluoro ou bromo, qui sont des inhibiteurs de métalloprotéinase de matrice.

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