Alpha-aminoacyl cephalosporin ethers

Details Alpha-aminoacyl cephalosporin ethers Alpha-aminoacyl cephalosporin ethers

C - Chemistry, Metallurgy

07

D

260/101.5

C07D 501/20 (2006.01)

Patent

CA 1097612

ABSTRACT The present invention relates to a process for preparing .alpha.-aminoacyl cephalosporins represented by the formula Image wherein R is phenyl, substituted phenyl, thienyl or furyl, R1 is hydrogen, methyl, ethyl or 3-methyl-2-butanyl; and R2 is hydrogen or an ester forming group. When R1 is other than hydrogen and R2 ic hydrogen the 3-cephem ethers provided by the process of this invention are valuable orally effective antibiotics, especially 7-(D-.alpha.-phenylglycylamido)-3-methoxy- 3-cephem-4-carboxylic acid. The 3-hydroxy cephalosporins (R1 = H, R2 = ester) are valuable intexmediates.

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