.alpha.-aminoketone derivatives

Details .alpha.-aminoketone derivatives .alpha.-aminoketone derivatives

C - Chemistry, Metallurgy

07

D

C07D 307/38 (2006.01) A61K 31/33 (2006.01) C07D 207/335 (2006.01) C07D 207/337 (2006.01) C07D 213/24 (2006.01) C07D 263/32 (2006.01) C07D 277/22 (2006.01) C07D 277/28 (2006.01) C07D 307/52 (2006.01) C07D 307/81 (2006.01) C07D 309/00 (2006.01) C07D 333/06 (2006.01) C07D 333/22 (2006.01) C07D 333/28 (2006.01) C07D 405/12 (2006.01) C07D 407/12 (2006.01) C07D 409/12 (2006.01)

Patent

CA 2111931

ABSTRACT OF THE DISCLOSURE Alpha-aminoketone derivatives of the present invention strongly inhibit thiol protease such as papain, cathepsin B, cathepsin H, cathepsin L and calpain or the like and have excellent properties in absorbance on oral administration, tissue distribution and cell membrane permeability. The alpha- aminoketone derivatives can thus be used as therapeutic agents for treating muscular dystrophy, amyotrophy, cardiac infarction, stroke, Alzheimer's disease, disturbance of consciousness or dyskinesia caused upon brain trauma, multiple sclerosis, peripheral nervous neuropathy, cataract, inflammation, allergosis, fulminant hepatitis, osteoporosis, hypercalcemia, breast carcinoma, prostatic carcinoma or prostatomegaly. It may also be used as therapeutic agents for suppressing growth of cancer cells, preventing metastasis of cancer or suppressing aggregation of plaques.

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