.alpha.-aminophosphonates and processes for their preparation

Details .alpha.-aminophosphonates and processes for their preparation .alpha.-aminophosphonates and processes for their preparation

C - Chemistry, Metallurgy

07

F

C07F 9/38 (2006.01) C07F 9/40 (2006.01) C07F 9/553 (2006.01) C07F 9/6506 (2006.01) C07F 9/655 (2006.01)

Patent

CA 2185728

.alpha.-Aminophosphonates are described as well as processes and intermediates for their preparation. In preferred embodiments, enantiomerically enriched .alpha.-aminophosphonates are prepared by the stereoselective addition of phosphite salts to chiral imines, These compounds have pronounced biological activities including inhibition of proteolytic enzymes and inhibition of bacterial growth.

Des .alpha.-aminophosphonates sont décrits, ainsi que des procédés et intermédiaires destinés à leur préparation. Dans des modes préféres de réalisation, on prépare des .alpha.-aminophosphonates à enrichissiment énantiomère en effectuant l'addition stéréosélective de sels de phosphite à des imines chirales. Ces composés présentent des activités biologiques intenses, telles que l'inhibition d'enzymes protéolytiques et de la croissance bactérienne.

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