.alpha.-aryl-4-substituted piperidinoalkanol derivatives

Details .alpha.-aryl-4-substituted piperidinoalkanol derivatives .alpha.-aryl-4-substituted piperidinoalkanol derivatives

C - Chemistry, Metallurgy

07

D

260/278.1, 260/2

C07D 211/00 (2006.01) C07D 211/22 (2006.01) C07D 211/70 (2006.01) C07D 401/06 (2006.01)

Patent

CA 1082703

Abstract of The Disclosure Novel compounds useful as antihistamine agents, antiallergy agents, and bronchodilators are represented by the following formula Image wherein R1 represents cyclohexyl, phenyl, or substituted phenyl wherein the substituent on the substituted phenyl is selected from halogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, or a lower alkoxy group of from 1 to 4 carbon atoms; R2 represents hydrogen or hydroxy; R3 represents hydrogen, or R2 and R3 taken together form a second bond between the carbon atoms bearing R2 and R3; n is an integer of from 1 to 3; Z represents thienyl, naphthyl, phenyl, or substituted phenyl wherein the substituent on the substituted phenyl may be attached at the ortho, meta or para position of the phenyl ring and is selected from halogen, a straight or branched alkyl group of from 1 to 6 carbon atoms, an alkoxy group of from 1 to 6 carbon atoms, a cycloalkyl group of from 3 to 6 carbon atoms, di(lower)alkylamino, or a saturated monocyclic heterocyclic group such as -1- pyrrolidino, piperidino, morpholino, or N-(lower)- alkylpiperazino with the proviso that when R' is phenyl, Z is naphthyl or phenyl substituted with a straight or branched alkyl group of 5 or 6 carbon atoms, a lower alkoxy group of 5 or 6 carbon atoms, or a cycloalkyl group of from 3 to 6 carbon atoms. Pharmaceutically acceptable acid addition salts and individual optical and geometric isomers of compounds of the above formula are also included as a part of this invention.

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