Alpha-aryl or heteroaryl-substituted amide ester acat...

Details Alpha-aryl or heteroaryl-substituted amide ester acat... Alpha-aryl or heteroaryl-substituted amide ester acat...

C - Chemistry, Metallurgy

07

C

C07C 235/80 (2006.01) A61K 31/215 (2006.01) A61K 31/275 (2006.01) A61K 31/33 (2006.01) C07C 233/11 (2006.01) C07C 233/29 (2006.01) C07C 255/60 (2006.01) C07C 323/41 (2006.01) C07D 213/56 (2006.01) C07D 215/14 (2006.01) C07D 217/16 (2006.01) C07D 239/26 (2006.01) C07D 307/54 (2006.01) C07D 333/24 (2006.01)

Patent

CA 2176042

Pharmaceutically useful compounds having acylcoenzyme A: cholesterol acyltransferase inhibitory activity having general formula (I) wherein Ar is di- or trisubstituted aryl or heteroaryl; R14 and R15 are each independently aryl, heteroaryl, hydrogen, fluorine, or alkyl, with the proviso that R14 and R15 are not both hydrogen, fluorine, or a straight or branched chain alkyl or a combination thereof; and R16 is a straight or branched hydrocarbon chain having 1 to 20 carbon atoms and is saturated or unsaturated and has 1 to 3 double bonds, the double bonds being adjacent or nonadjacent.

L'invention se rapporte à des composés pharmaceutiques exerçant une activité inhibitrice de l'acyle-coenzyme A: cholestérol acyltransférase, ayant la formule générale (I) dans laquelle Ar représente aryle ou hétéroaryle à di- ou tri- substitution; R¿14? et R¿15? représentent chacun indépendamment aryle, hétéroaryle, hydrogène, fluor ou alkyle, à la condition que R¿14? et R¿15? ne représentent pas tous deux hydrogène, fluor ou un alkyle à chaîne droite ou ramifiée, ou une combinaison de ceux-ci; et R¿16? représente une chaîne hydrocarbure droite ou ramifiée possédant de 1 à 20 atomes de carbone, est saturé ou insaturé et possède 1 à 3 liaisons doubles adjacentes ou non.

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