Alpha b-crystallin as a therapy for inflammation

Details Alpha b-crystallin as a therapy for inflammation Alpha b-crystallin as a therapy for inflammation

A - Human Necessities

61

K

A61K 38/17 (2006.01) A61K 38/16 (2006.01) A61K 45/00 (2006.01) A61K 47/48 (2006.01) A61P 25/24 (2006.01) A61P 25/28 (2006.01) A61P 29/00 (2006.01) A61P 37/06 (2006.01)

Patent

CA 2671724

The invention provides methods for treating inflammatory diseases by administering to the subject an effective amount of an agent that provides alpha B-crystallin activity, where the dose is effective to suppress or prevent initiation, progression, or relapses of disease, including the progression of established disease. In some embodiments, the methods of the invention comprise administering to a subject having a pre-existing inflammatory disease condition, an effective amount of alpha B-crystallin protein, to suppress or prevent relapses of the disease.

La présente invention concerne des procédés de traitement des maladies inflammatoires par l'administration au sujet d'une quantité efficace d'un agent qui présente une activité alpha B-cristalline, la dose étant efficace pour supprimer ou prévenir l'apparition, la progression ou les rechutes d'une maladie, y compris la progression d'une maladie établie. Selon certains modes de réalisation, les procédés de l'invention comprennent l'administration à un sujet atteint d'une maladie inflammatoire pré-existante d'une quantité efficace de protéine alpha B-cristalline afin de supprimer ou d'éviter les rechutes de la maladie.

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