.alpha.,.beta.-unsaturated esters and acids by...

Details .alpha.,.beta.-unsaturated esters and acids by... .alpha.,.beta.-unsaturated esters and acids by...

C - Chemistry, Metallurgy

07

D

C07D 231/12 (2006.01)

Patent

CA 2570320

There are provided by the present invention certain pyrazole based CCK-1 receptor modulators which have the general formula: wherein Ar is an aromatic or heteroaromatic group, X is a hydrocarbon linker, Y is a bond or hydrocarbon linker and R1, R2, R3, R4 and R5 are certain organic substituents, methods for making the same, and stereoselective dehydration methods for generally making .alpha.,.beta.-unsaturated esters, acids and their derivatives.

La présente invention a trait à des modulateurs de récepteur CCK-1 à base de pyrazole de formule générale (I), dans laquelle Ar est un groupe aromatique ou hétéroaromatique; X est un lieur hydrocarboné; Y est une liaison ou un lieur hydrocarboné; et R1, R2, R3, R4 et R5 sont des substituants organiques. L'invention a également trait à des procédés pour la fabrication desdits modulateurs, et à des procédés de déshydratation stéréosélective pour la fabrication d'esters, d'acides .alpha.,.beta.-insaturés et leurs dérivés.

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