Alpha, beta-unsaturated sulfones, sulfoxides, sulfonimides,...

Details Alpha, beta-unsaturated sulfones, sulfoxides, sulfonimides,... Alpha, beta-unsaturated sulfones, sulfoxides, sulfonimides,...

C - Chemistry, Metallurgy

07

C

C07C 317/14 (2006.01) A61K 31/10 (2006.01) A61K 31/18 (2006.01) A61K 31/275 (2006.01) A61P 35/00 (2006.01) C07C 311/15 (2006.01)

Patent

CA 2577309

.alpha.,.beta.-Unsaturated sulfones, sulfoxides, sulfonimides, sulfinimides, acylsulfonamides and acylsulfinamides of Formula I: wherein R1 R2, M1 M2,L, E1 , E2, Q1, Q2 and n are as defined herein, are useful as anti-angiogenesis agents, as agents for treatment of age related senile dementia, and as antiproliferative agents including, for example, as anticancer agents.

L'invention concerne des sulfones, sulfoxydes, sulfonimides, sulfinimides, acylsulfonamides et acylsulfinamides insaturés a,ß de la formule I où R1 R2, M1 M2,L, E1 , E2, Q1, Q2 et n ont la définition donnée. Ils sont utiles comme agents anti-angiogénèse, comme agents de traitement de l'âge lié à la démence sénile, et comme agents antiprolifératifs et, par exemple, comme agents anticancer.

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