C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 233/54 (2006.01) A61K 49/04 (2006.01) C07C 69/76 (2006.01) C07C 233/88 (2006.01) C07C 237/46 (2006.01) C07C 255/20 (2006.01) C07C 311/24 (2006.01) C07C 317/46 (2006.01) C07D 295/185 (2006.01)
Patent
CA 2191984
Compounds having structure (I) wherein m is 1, 2, 3 or 4; Z-(-COO-)-m is the residue of a polyiodinated aromatic mono- or polyacid; R1 is H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, alkoxyalkyl or acetamidoalkyl; n is an integer from 0 to 20; R2 is cycloalkyl or aryl; and R3, R4 and R5 are independently H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, halogen, hydroxy, acylamino, acetamidoalkyl, cyano, sulfonyl, carboxamido or sulfonamido are useful as x-ray contrast agents in medical diagnostic x-ray imaging compositions and methods.
L'invention concerne des composés de structure (I) où m est égal à 1, 2, 3, ou 4; Z-(-COO-)-¿m? est le reste d'un monoacide ou d'un polyacide aromatique polyiodé; R?1¿ représente H, alkyle, fluoroalkyle, cycloalkyle, aryle, aralkyle, alcoxyalkyle ou acétamidoalkyle; n est un entier compris entre 0 et 20; R?2¿ représente cycloalkyle ou aryle; et R?3¿, R?4¿ et R?5¿ représentent indépendamment l'un de l'autre H, alkyle, fluoroalkyle, cycloalkyle, aryle, aralkyle, halogène, hydroxy, acylamino, acétamidoalkyle, cyano, sulfonyle, carboxamido ou sulfonamido. Ces composés sont utilisés en tant qu'agents de contraste pour rayons X dans des compositions et des procédés d'imagerie par rayons X destinés au diagnostic médical.
Bacon Edward R.
Illig Carl R.
Osifo Irennegbe K.
Peng Xin
Toner John L.
Nanosystems L.l.c.
Smart & Biggar
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