Alpha-fetoprotein immu31 antibodies and fusion proteins and...

Details Alpha-fetoprotein immu31 antibodies and fusion proteins and... Alpha-fetoprotein immu31 antibodies and fusion proteins and...

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 49/16 (2006.01) A61K 51/10 (2006.01) A61P 35/00 (2006.01) C07K 16/18 (2006.01) C07K 16/30 (2006.01) C07K 16/46 (2006.01) C12N 5/10 (2006.01) C12N 15/62 (2006.01) G01N 33/574 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2494310

The present invention provides humanized, chimeric and human anti-alpha- fetoprotein antibodies, fusion proteins, and fragments thereof. The antibodies, fusion proteins, and fragments thereof, as well as combinations with other suitable antibodies, are useful for the treatment and diagnosis of hepatocellular carcinoma, hepatoblastoma, germ cell tumors carcinoma and other AFP-producing tumors.

L'invention concerne des anticorps anti-alpha-fétoprotéine humanisés, chimères et humains, des protéines de fusion et des fragments de ceux-ci. Ces anticorps, protéines de fusion et leurs fragments, ainsi que leurs combinaisons avec d'autres anticorps appropriés sont utiles dans le traitement et le diagnostic du carcinome hépatocellulaire, de l'hépatoblastome, des tumeurs des cellules germinales et d'autres tumeurs produisant l'AFP.

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