Alpha-fetoprotein peptides and uses thereof

Details Alpha-fetoprotein peptides and uses thereof Alpha-fetoprotein peptides and uses thereof

C - Chemistry, Metallurgy

07

K

C07K 14/47 (2006.01) A61K 31/138 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61P 35/00 (2006.01) C07K 7/06 (2006.01) C07K 16/18 (2006.01) C12N 5/00 (2006.01)

Patent

CA 2449284

The subject invention addresses the need for methods of treatment and prevention of breast cancer, and other cancers, by providing a peptide of eight to twenty amino acids in length which comprises a hydrophilic analog of an alpha-fetoprotein peptide having SEQ ID NO:6: EMTPVNPG. The peptides may be linear, but are preferably cyclic. The peptides may be provided as dimers or other multimers. A composition comprising the peptide, and antibody that specifically binds to the peptide, a method of reducing estrogen-stimulated growth of cells using the peptides, as well as a method of treating or preventing cancer, such as breast cancer, are also provided. The treatment or prevention method can include the use of tamoxifen therapy in combination with the peptide therapy.

L'invention traite de la nécessité de trouver des procédés de traitement et de prévention du cancer du sein, et d'autres cancers. Ces procédés utilisent un peptide huit à vingt acides aminés en longueur, qui comprend un analogue hydrophile d'un peptide d'alpha-fétoprotéine possédant la SEQ ID NO :6 : EMTPVNG. Ces peptides peuvent être linéaires, mais sont de préférence cycliques. Ces peptides peuvent être fournis sous forme de dimères ou d'autres multimères. L'invention concerne aussi une composition comprenant le peptide, un anticorps qui se lie de manière spécifique au peptide, un procédé de réduction de la croissance cellulaire stimulée par les oestrogènes en utilisant le peptide, ainsi qu'un procédé de traitement ou de prévention du cancer, comme le cancer du sein. Ce procédé de traitement ou de prévention peut comprendre la thérapie par le taxomifène en association avec la thérapie par les peptides.

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